| Saber Envelhecer | Cícero | — | — |
| Sabha Parva | Vyasa | — | — |
| Saga de Egil Skallagrimsson | Snorri Sturluson | — | — |
| Saga de Njáll o Queimado | — | — | — |
| Sahih al-Bukhari | Albucari | — | — |
| Salammbô | Gustave Flaubert | 1862 | — |
| Salomé | Oscar Wilde | — | — |
| Samguk sagi | Kim Pusik | 1145 | — |
| Samguk Yusa | Il-yeon | 1279 | — |
| Sans Famille | Hector Malot | 1878 | — |
| Sapiens: Uma Breve História da Humanidade | Yuval Noah Harari | 2011 | — |
| Satíricon | Petrônio | — | — |
| Schachnovelle | Stefan Zweig | 1943 | — |
| Schindler's Ark | Thomas Keneally | 1982 | — |
| Scrolls of Abraham | Deus no Islã | — | — |
| SCUM Manifesto | Valerie Solanas | 1967 | — |
| Se um Viajante Numa Noite de Inverno | Italo Calvino | 1979 | — |
| Segunda Fundação | Isaac Asimov | 1953 | — |
| Segundo Alcibíades | Platão | — | — |
| Seis Personagens à Procura de um Autor | Luigi Pirandello | 1921 | — |
| Sem Destino | Imre Kertész | 1975 | — |
| Sem logo | Naomi Klein | 1999 | — |
| Sense and Sensibility | Jane Austen | 1811 | — |
| Servidão humana (Barata 1959) | W. Somerset Maugham | 1915 | — |
| Sete Anos no Tibete | Heinrich Harrer | 1952 | — |
| Sete Sábios | Syntipas | 1696 | — |
| Sex | Steven Meisel, Madonna | 1992 | — |
| Shahnameh | Ferdusi, Abu-Mansur Daqiqi | — | — |
| Shan Hai Jing | Guo Pu | — | — |
| Shantaram | Gregory David Roberts | 2003 | — |
| Shield of Heracles | Pseudo-Hesiod | — | — |
| Shirley | Charlotte Brontë | 1849 | — |
| Shoku Nihongi | Sugano no Mamichi, Fujiwara no Tsuginawa | — | — |
| Shrek! | William Steig | 1990 | — |
| Shulkhan Arukh | Yosef Karo | 1565 | — |
| Shuowen Jiezi | Xu Shen | — | — |
| Sidarta | Hermann Hesse | 1922 | — |
| Sidereus Nuncius | Galileu Galilei | 1610 | — |
| Siku Quanshu | vários autores | 1787 | — |
| Silas Marner | George Eliot | 1861 | — |
| Silent Spring | Rachel Carson | 1962 | — |
| Silver Blaze | Arthur Conan Doyle | 1892 | — |
| Silêncio | Shusaku Endō | 1966 | — |
| Sir Gawain e o Cavaleiro Verde | Poeta de Pearl | — | — |
| Sister Carrie | Theodore Dreiser | 1900 | — |
| Six Thinking Hats | Edward de Bono | 1985 | — |
| Skeleton Crew | Stephen King | 1985 | — |
| Skáldskaparmál | Snorri Sturluson | — | — |
| Sleeping Murder | Agatha Christie | 1976 | — |
| Smith of Wootton Major | J. R. R. Tolkien | 1967 | — |
| Snow | Orhan Pamuk | 2002 | — |
| Snow Crash | Neal Stephenson | 1992 | — |
| Snow-White and Rose-Red | Irmãos Grimm | 1827 | — |
| Sobre a Questão Judaica | Karl Marx | 1843 | — |
| Sobre o Céu | Aristóteles | — | — |
| Sobre os Judeus e Suas Mentiras | Martinho Lutero | 1543 | — |
| Sofista (diálogo) | Platão | — | — |
| Solaris | Stanisław Lem | 1961 | — |
| Sombras da Noite | Stephen King | 1978 | — |
| Some Thoughts Concerning Education | John Locke | — | — |
| Soneto 1 | William Shakespeare | 1609 | — |
| Soneto 18 | William Shakespeare | 1609 | — |
| Sonetos de Shakespeare | William Shakespeare | 1609 | — |
| Sourcery | Terry Pratchett | 1988 | — |
| South of the Border, West of the Sun | Haruki Murakami | 1992 | — |
| Sparkling Cyanide | Agatha Christie | 1945 | — |
| Speaker for the Dead | Orson Scott Card | 1986 | — |
| Species Plantarum | Lineu | — | — |
| Sputnik Sweetheart | Haruki Murakami | 1999 | — |
| Stabat Mater | Jacopone da Todi | — | — |
| Stardust | Neil Gaiman | 1999 | — |
| Starship Troopers | Robert A. Heinlein | 1959 | — |
| Steve Jobs | Walter Isaacson | 2011 | — |
| Strange Case of Dr Jekyll and Mr Hyde | Robert Louis Stevenson | 1886 | — |
| Stranger in a Strange Land | Robert A. Heinlein | 1961 | — |
| Strategikon de Maurício I | Maurício I | — | — |
| Submissão | Michel Houellebecq | 2015 | — |
| Suda | vários autores | — | — |
| Sunan Abu Dawood | Abu Dawood | — | — |
| Sunan ibn Majah | Ibne Maja | — | — |
| Surely You're Joking, Mr. Feynman! | Richard Feynman, Ralph Leighton | 1985 | — |
| Surya Siddhanta | Lāṭadeva | — | — |
| Sushruta Samhita | Sushruta | — | — |
| Sutra do Coração | Siddhartha Gautama | — | — |
| Svinedrengen | Hans Christian Andersen | 1841 | — |
| Syntactic Structures | Noam Chomsky | 1957 | — |
| Systema Naturae | Lineu | 1735 | — |
| Sêfer Yetzirá | Abraão | — | — |
| Ṣaḥīḥ Muslim | Muslim ibne Alhajaje | — | — |